On the heels of 2005’s blockbuster The 40-Year-Old Virgin, writer/director Judd Apatow again mines hilarity from the relatably human in a comedy about a one-night stand with unexpected consequences: Knocked Up. Katherine Heigl (Grey’s Anatomy, Roswell) joins Virgin alums Seth Rogen, Paul Rudd and Leslie Mann for a comic look about the best thing that will ever ruin your best-laid plans: parenthood.