i have a mac pro 4.1 can i run two 8 gig memory modules instead of three memory modules?

I have an older mac pro, NOT a macbook pro, model 4.1. I was told that you should place three of the same mem modules e.g. 44and4 not just two such as 4 and 4. If i were to place in two 8 gig memory modules would they work and work as well as three of the same ?

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